News FeedComparative genomics includes the computational analysis of coding and
regulatory DNA sequences from multiple genomes to identify patterns of
similarity conserved during evolution and that constitute functional
elements responsible for the regulated expression of genes and the targetting of
proteins.
This project will develop and apply computational comparative genomics
techniques to understand the evolution, targetting and regulation of
nuclear-encoded genes that participate in mitochondrial biochemical and
bioenergetic processes. Of particular interest will be the mitochondrial
carrier family, which are required for the translocation of metabolites
between the matrix and cytosol. Whilst some of these carriers have been
characterised and shown to be vital for essential biochemical pathways, the role of
many others is unknown.
Current work has seen the establishment of an IT infrastructure for the
computational identification and storage of conserved non-coding
elements across metazoan species.
(Full funding available for UK applicants; fees-only for EU applicants;
others can apply if they wish)
Applications to Mrs. Penny Peck
http://www.mrc-dunn.cam.ac.uk/people/robinson_alan/