News FeedThe involvement of the mitochondrion in many vital cellular processes
makes its proteins an attractive proposition for structural studies. Such studies
frequently require an inhibitory small molecule to stabilise the protein.
This project will incorporate comparative modelling of protein targets,
virtual compound screening and in silico lead optimisation in order to identify
candidate inhibitory molecules of mitochondrial proteins. The project
will require the development and refinement of techniques for the application
of these methods to membrane proteins. In the first stage of the project,
the focus will be on designing inhibitors to members of the mitochondrial
carrier family.
The project will be in collaboration with the group of Dr. Edmund Kunji,
whose group will test the inhibitory capacity of candidate molecules in
transport assays and their efficacy in crystallisation trials.
The successful candidate should have a background in the chemical or
life sciences, as well as bioinformatics experience.
(Full funding available for UK applicants; fees-only for EU applicants;
others can apply if they wish)
Applications to Mrs. Penny Peck
http://www.mrc-dunn.cam.ac.uk/people/robinson_alan/